Attempt to assess direct interactions between tumor burden, myeloid-derived suppressor cells and PD-1- and TIM-3-expressing T cells in multiple myeloma patients
نویسندگان
چکیده
The avoidance of immune surveillance by malignant plasma cells (PCs) in multiple myeloma (MM) is mediated different mechanisms, among which an induction T cell exhaustion and expansion myeloid-derived suppressor (MDSCs) appear to play substantial roles, but it still a lack data on possible MDSC-mediated exhaustion. aim the present work was evaluate relationship between frequencies MM PCs, MDSCs phenotypically exhausted PD-1 + TIM-3 bone marrow (BM) samples peripheral blood (PB) patients at various disease stages. Peripheral (n = 88) BM 56) were obtained from (newly diagnosed 6), remission 71) with progressive 11)). Frequencies expressing checkpoint receptors TIM-3, polymorphonuclear (PMN-MDSCs, Lin - CD14 HLA-DR CD33 CD15 /CD66b ), monocyte (M-MDSCs, low/- early (E-MDSCs, PCs (CD45 dim CD38 CD138 CD56 CD19 CD117 CD27 CD81 ) assessed flow cytometry. Circulating BM-resident /TIM-3 subsets, E-MDSCs, as soon serum beta2-microglobulin (B2-M) levels gradually increased Despite that, there no associations markers tumor load studied subsets. In remission, PMN-MDSCs negatively correlated CD4 cells, CD8 subsets; positive correlations E-MDSCs PB M-MDSCs (as trend) cells. We found for diagnosis progression. can conclude that mutual influence nonlinear, especially during manifest growth detected negative resident PMN- subsets might be associated MDSC suppressive function, affecting both predominantly activated CD4+PD-1 subset circulating confirm ability induce
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ژورنال
عنوان ژورنال: ??????????? ???????????
سال: 2023
ISSN: ['2409-5788']
DOI: https://doi.org/10.15789/1563-0625-ato-2760